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SYNTHESIS, DIAGNOSIS, BIOLOGICAL ACTIVITY FOR SOME SUBSTITUTED TETRAZOLE DERIVED FROM METHYL 2-(p-TOLYL) BENZOATE

Linda R. AbdulRaheem¹, Aws N . Abdlaziz¹, Mohammed H . Ali¹, Khalid A. Alalbadrany²

Abstract: Drug-resistant bacteria—including multidrug-resistant strains, persistent infections, and emerging pathogens—continue to spread rapidly, posing a serious threat to global public health. This situation highlights the urgent need to develop new, highly effective antimicrobial agents. In this study, a series of tetrazole derivatives were synthesized as…

Keywords: Tetrazole, Hydrazones, Hydrazide, Biological activity.

DOI: 10.65382/2221-8688-2026-3-451-464

SYNTHESIS AND CHARACTERIZATION OF COORDINATION COMPLEXES DERIVED FROM A CARBAZOLE-BASED SCHIFF BASE LIGAND WITH TRANSITION METALS AND ZINC, AND EVALUATION OF THEIR BIOLOGICAL ACTIVITY

F.T. Saeed^1*, E.A. Sulliman²

Abstract: A new Schiff base ligand obtained from carbazole was synthesized and structurally characterized. Its coordination complexes with Co (II), Ni (II), Cu (II), and Zn (II) ions were prepared for the first time and investigated through various spectroscopic techniques, including ¹H-NMR, UV-Vis, and FT-IR.…

Keywords: carbazole, transition metal complexes, DFT, biological activity, coordination chemistry

DOI: 10.65382/2221-8688-2026-3-416-429

SYNTHESIS, CHARACTERIZATION, AND ANTI-CANCER ACTIVITY OF ZINC(II)COMPLEXES WITH A MIXTURE OF 1H-TETRAZOLE LIGANDS-(BENZYLTHIO)-5LICATES AND PHOSPHINES AND THEIR BIOLOGICAL ACTIVITY

A.H. Ali

SYNTHESIS AND CHARACTERIZATION OF Mn⁺², Co⁺², Ni⁺², Cu⁺² AND Zn⁺² COMPLEXES WITH 4-(2-(BENZO-1,3-DIOXOL-5-YL)-4,5-DIPHENYL-2,5-DIHYDRO-1H-IMIDAZOL-1-YL)ANILINE AND EVALUATION OF THEIR BIOLOGICAL ACTIVITY

Roaa R. Abdljabar, Farah T. Saeed

The aim of this work was to create new ligand complexes and evaluate their effectiveness against certain strains of bacteria. A Brucker Tensor 27co FTIR spectrophotometer was used to record the infrared spectra. Elemental analysis (C, H, N) was carried out on an AA670 atomic…

DOI: 10.32737/2221-8688-2024-2-197-210

SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION FOR ESTER DERIVATIVES FROM SOME NSAIDS DRUGS

Saif Y. Ahmed, *Nabeel A. Abdul-Rida

Abstract: The current research involves the synthesis of some NSAID derivatives and evaluating their antimicrobial and antioxidant activity. Briefly, some NSAID compounds were converted into ester derivatives using the Fischer esterification method. The synthesized compounds were spectrometrically characterized via modern methods FT-IR, 1H-NMR, and 13C-NMR…

Keywords: NSAIDs drugs, Antioxidant, Fischer-esterification, Antimicrobial

DOI: 10.65382/2221-8688-2026-1-55-61

SYNTHESIS, CHARACTERIZATION, STUDY OF MOLECULAR DOCKING AND BIOLOGICAL ACTIVITY OF MIXED LIGANDS PLATINUM (II) COMPLEXES WITH 2-((5-CHLOROQUINOLIN-8-YL) OXY) ACETOHYDRAZIDE AND TERTIARY DI PHOSPHINES

Afraa Sabir Shihab

This study involves the preparation of various organic compounds. Ethylnyl 2-((5-chloroquinolin- 8-yl)oxy)acetate compound (A1) was synthesized by adding Potassium carbonate to quinoline and ethyl chloroacetate. The 2-((5-Chloroquinolin-8-yl)oxy) acetohydrazide (A2) was prepared by reacting compound (A1) with hydrazide. Complex of (A3) were obtained by reacting equimolar…

DOI: 10.32737/2221-8688-2024-4-525-539

PREPARATION, CHARACTERIZATION, AND STUDY OF THE BIOLOGICAL ACTIVITY OF 5-CHLORO-8-QUINOLINOL DERIVATIVES AND ITS COORDINATION WITH THE NICKEL (II) AND DIPHOSPHINES

Sakar M. Abdalrazaq, Afraa S. Shihab, Iyad S. Hamad

Nickel complexes are effective catalysts for cross-coupling reactions between alkyl Grignard reagents and alkenyl–S and alkenyl–Se compounds. In this study, various organic compounds were prepared. Ethylnyl 2-((5-chloro-8-quinolinol)oxy) acetate compound (designated as A1) was synthesized by ‎adding potassium carbonate to quinoline and ethyl chloroacetate. The second…

DOI: 10.32737/2221-8688-2024-2-157-167

SYNTHESIS OF SOME NEW THEOPHYLLINE DERIVATIVES USING CLICK CHEMISTRY AND STUDY OF BIOLOGICAL ACTIVITY

Ruaa J. Kamel, Nabeel A. Abdul-Rida

In this study, the authors chemically synthesized new theophylline derivatives and then evaluated them in vitro as antimicrobial agents. The target derivatives, theophylline derivatives conjugated with 1,2,3- triazole and piperazine moieties, were synthesized via sequential various reactions. Spectroscopically, the researchers employed FT-IR, 1H NMR, and…

DOI: 10.32737/2221-8688-2025-4-549-555

BENZAMINE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY

Zahraa S. Qasim, Kareem S. Abbas

Our study is included the synthesis of a number of benzamide drivatives through two chemical processes. The first is the benzoylation of some aromatic amines containing a pyrimidine or a pyrazoline ring in their structures (A-G) using benzoyl chloride or p-chloronbenzoyl chloride in the presence…

DOI: 10.32737/2221-8688-2024-4-411-435

SYNTHESIS, DIAGNOSIS, EVALUATION OF BIOLOGICAL ACTIVITY AND STUDY OF MOLECULAR DOCKING FOR FUROSEMIDE DERIVATIVE AND ITS COORDINATION WITH SOME METALS

Afraa Sabir Shihab

This study includes the preparation and characterization of new compound (4-bromo-5-(N-((4- chlorophenyl) (1,1-dioxide-3-oxobenzo isothiazol-2(3H)-yl)methyl)sulfamoyl)-2-((furan- 2-ylmethyl)amino)benzoic acid) from the reaction of furosemide, Saccharin and p-bromo benzaldehyde in a molar ratio 1:1:1 in ethanol. All the complexes are prepared from the reaction of Mannich bases with metal…

DOI: 10.32737/2221-8688-2024-3-312-323

PREPARATION, IDENTIFICATION AND STUDY THE BIOLOGICAL ACTIVITY OF NOVEL HETEROCYCLIC COMPOUNDS DERIVED FROM AZO–CHALCONE

Ruwa M. Mauf , Neam H. Saleem

This work describes the preparation and spectroscopic investigation of new heterocyclic compounds derived from the 4-aminoantipyrene moiety. The compound (R1)3-((1,5-dimethyl-3-oxo-2- phenyl-2,3-dihydro-1H-pyrazol-4-yl)diaz-enyl)-4-hydroxybenzaldehyde was prepared by reacting 4- aminoantipyrene with 4-Hydroxybenzaldehyde according to the cold condition at (0-5) Celsius. This represents the starting point to create novel…

DOI: 10.32737/2221-8688-2025-2-272-285

SYNTHESIS AND CHARACTERIZATION OF FIVE-MEMBERED HETEROCYCLIC COMPOUNDS OF TETRAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

Sara L. Khalil, Neam H. Saleem

ANALYSIS OF IONIZATION BEHAVIOR AND THERMODYNAMIC PARAMETERS OF SCHIFF BASES UNDER SOLVENT EFFECTS: AN ELECTRICAL STUDY WITH MOLECULAR DOCKING-BASED BIOLOGICAL ACTIVITY EVALUATION

A.A. Aldabagh, F.H.M. Altaiea

SYNTHESIS AND CHARACTERIZATION OF Co+2, Ni+2, Cu+2 and Cd+2 COMPLEXES WITH (4-(TERT-BUTYL) BENZENETHIOL) ALKANE LIGANDS AND EVALUATION OF ITS BIOLOGICAL ACTIVITY

Shahad A. Qasim, Farah T. Saeed^*

The research demonstrates that thioether-based coordination complexes obtain their physicochemical properties and biological activity from both the metal ion type and the ligand molecular structure. The synthesized complexes showed tetrahedral coordination geometries, as evidenced by spectroscopic, magnetic, and conductivity measurements, which demonstrated that sulfur atoms…

Keywords: Thioether ligands; Disulfide derivatives; Coordination complexes; Tetrahedral geometry; Antimicrobial activity; Transition metals

DOI: 10.65382/2221-8688-2027-1-65-77

CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF POLYACRYLIC ACID MODIFIED WITH SEVERAL ALDEHYDES USING BENZIDINE AS A SPACER

A.R. Kadhim, S.A. Aowda, M.M. Kareem^*

Polyacrylic acid has been utilized to react with a variety of substances to create novel compounds with biological activity because it is a recognized safe material to work with. In this work, the AB chemical was created by reacting polyacrylic acid with benzidine. It was…

Keywords: polyacrylic acid, biological activity, Schiff-base compounds, anti-oxidant activity.

DOI: 10.65382/2221-8688-2027-1-112-127

ANALYSIS OF ANTIOXIDANT ACTIVITY OF EPOXIAMINES AND BIOLOGICAL ACTIVITY OF 1,3-DIAMINOPROPANOLS-2

I.Sh.Huseynov, S.B.Zeynalov

Analysis of epoxiamines and aminospirits obtained from the interaction of epichlorhydrine with amines has been conducted. Antioxidant activity of epoxiamines and biological activity of aminospirits including antifungus and ontibacterial action aminospirits have been examined.

SYNTHESIS OF OXAZEPINO COMPOUND VIA ELECTROPHILIC CYCLIZATION AND EVALUATION OF THEIR BIOLOGICAL ACTIVITY

Hayfa Al-Badrani, Nameer S. Ezzat, Yassir S. Al-Jawaheri

In this research paper, we successfully synthesized some of E-1-(iodomethy-lene)-8-(aryl)-1,2,7,8- tetrahydro-9H benzo[6,7][1,4]oxazepino [4,5-a] quinazolin-9-one (compounds 3a-f) through electrophilic cyclization of 3-aryl-2-(2-(prop-2-yn-1-yloxy) phenyl)-2,3-dihydroquinazolin-4(1H)-one derivatives (compounds 2a-f) using iodine as an electrophilic source and potassium carbonate as a base in dichloromethane at room temperature in good yield.…

DOI: 10.32737/2221-8688-2025-3-343-355

SINTHESIS OF H-(2-CYKLOHEXILPIRRIL)-VINE QAZ ACID AND RESEARCH INTO BIOLOGICAL ACTIVITY OF THEIR SODIUM SALT

V.Q.Ibrahimov, E.I.Mammadov, O.I.Quliyeva

H-(2-cyclohexilpirril) acetic acid has been synthesized through the reaction of cyclohexil β,γ-dichlorketon with glycin in the water solution of alkali. Biological activity of sodium salt of the synthesized acid has been tested in comparison with heteroacetik and hybberel acids. It has been established that it…

SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW DITHIOCARBAMATE DERIVATIVES

C.Y. Shukurov

Nowadays there are various antifungal agents. These included many substances, including derivatives of dithiocarbamates. The article aims to synthesize new derivatives of dithiocarbamate and study their antifungal activity. To analyze and identify synthesized substances and determine their structural formulas, the following spectral methods were used:…

DOI: 10.32737/2221-8688-2020-2-174-180

SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF VARIOUS NEW SCHIFF BASES ASSOCIATED WITH THE 9,10-DIHYDRO-9,10-[3,4]FURANOANTHRACENE-12,14-DIONE GROUP

Zina L. Khaleel, Yassir S. Al-Jawaheri

A series of novel Schiff bases linked to Furanoanthracene-12,14-Dione (5-10) were synthesized. The first step involved the reaction of anthracene with maleic anhydride, which produced dione (1). The next step was treated the dione with aniline to produce the imide (2). In the third step,…

DOI: 10.32737/2221-8688-2025-3-433-442