This work describes the preparation and spectroscopic investigation of new heterocyclic compounds derived from the 4-aminoantipyrene moiety. The compound (R1)3-((1,5-dimethyl-3-oxo-2- phenyl-2,3-dihydro-1H-pyrazol-4-yl)diaz-enyl)-4-hydroxybenzaldehyde was prepared by reacting 4- aminoantipyrene with 4-Hydroxybenzaldehyde according to the cold condition at (0-5) Celsius. This represents the starting point to create novel…

DOI: 10.32737/2221-8688-2025-2-272-285

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SYNTHESIS OF AROMATIC-HETEROCYCLIC AMINO ALCOHOLS AND INVESTIGATION OF THEIR ANTIBACTERIAL AND PHYSIOLOGICAL PROPERTIES

K.Kurbanli, S.Malkondu

Amino alcohols are important compound in point of physiological activity. A number of aromatic and heterocyclic amino alcohols were efficiently prepared and characterized by using spectroscopic data. They were also evaluated for antibacterial activity against both Gram-positive and Gram-negative bacteria in vitro comparable to cefalexin.…

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SYNTHESIS, CHARACTERIZATION, AND PHARMACEUTICAL ACTIVITY OF FUSED TRIAZOLOTHIADIAZOLE DERIVATIVES

⃰Bassam A. Hassan¹, Fadil M.Hamed2 and Athraa Hameed Mekky³

Abstract: A series of fused heterocyclic compound Triazolothiadiazole Derivatives 4a-4f was produced by treating 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol (3) with aryl aldehydes in the presence of KOH. The new triazolothiadiazole derivatives demonstrated anticancer efficacy through docking with the EGFR tyrosine kinase receptor protein, evidenced by docking scores ranging…

Keywords: heterocyclic compound, aryl aldehydes, triazolothiadiazole, anticancer, cytotoxic activity, molecular docking

DOI: 10.32737/2221-8688-2025-4-465-475

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PREPARATION, BIOLOGICAL EVALUATION, AND APPLICATION OF THIADIAZOLE, SCHIFF BASE, AND TETRAZOLINE DERIVATIVES DERIVED FROM AQUEOUS MORINGA LEAF EXTRACTS: POM ANALYSIS FOR PHARMACOPHORESITE IDENTIFICATION

Hadil M. Salih^1,2, Sanaa A. Abd-Alkareem¹

Moringa oleifera leaves have long been used in conventional medicine to treat a variety of ailments, including fever and sore throat. The close relationship between plants and human health has promoted the development of plant-based therapies, such as pharmaceuticals and nutritional supplements, thereby advancing traditional…

Keywords: Nitril Compounds, thiourea, Schiff bases, cyclic addition reaction, tetrazoline, heterocyclic.

DOI: 10.65382/2221-8688-2027-1-181-191

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SYNTESIS AND ANALYSIS OF MIXED LIGAND COMPLEXES OF SOME HETEROCYCLES OF AMINS WITH TETRAMETYLETHYLENDIAMIN OF PLATINUM (III)

A.N.Azizova(Shikhaliyeva), Sh.H.Gasimov, Kh.I.Hasanov, J.I.Mirzai

A mixed ligand complex of some heterocycles of amines with tetrametylethylendiamin of platinum (III) with heterocyclic amines has first ever been synthesized. Composition and structure of synthesized complexes has been studied through present-day physical-chemical methods. It is apparent that in all cases heterocyclic amines correlate…

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FUSED RING HETEROCYCLE FUNCTIONALIZED GOLD NANOPARTICLES: SYNTHESIS AND SELF-ASSEMBLY

Saurav Paul, Bimal B. Chakraborty, Kuheli Deb, Sudip Choudhury

Self-assembled nanoparticles are an area of great research prospect as they offer switchable element for designing and creating micro-scale constructs. Self-assembly of nano-hybrids through some non- covalent interactions such as electrostatic, π-π and van der Waal interactions in different classes of composite materials provide a…

DOI: 10.32737/2221-8688-2023-2-188-196

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SYNTHESIS AND CHARACTERIZATION OF SOME HYDRAZONE AND THIAZOLIDINE DERIVATIVES AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY

F. Mohammed^*, K. Al-Badrany

Abstract: In this study, hydrazone and thiazolidine derivatives were synthesized. The hydrazone derivatives (F2–F6) were prepared from 3-bromomethylbenzohydrazide, followed by their reaction with thioglycolic acid to form thiazolidine derivatives (F7–F11). The structures of the synthesized compounds were confirmed through physical changes, such as variations in…

Keywords: Heterocyclic, Hydrazone, Thiazolidine, Biological activity

DOI: 10.65382/2221-8688-2026-3-476-486

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PREPARATION AND CHARACTERIZATION OF INDOLE-3-CARBALDEHYDE-DERIVED PYRAZOLINE DERIVATIVES AND EVALUATION OF BIOLOGICAL EFFICACY

J.H. Saleh, M.G. Abdulkarim

Abstract: The research involved the preparation of a series of chalcones [I1-I5] by the reaction of indole-3-carbaldehyde with acetophenone substituents in a basic medium. The prepared chalcones were then reacted with aqueous hydrazine in the presence of glacial acetic acid as a catalyst to form…

Keywords: heterocyclic; chalcones; pyrazoline; biological activity

DOI: 10.65382/2221-8688-2026-4-599-569

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SYNTHESIS AND APPLICATION OF S-SUBSTITUTED TIIRANS

N.A.Akberov, M.A.Mirzayeva, L.A.Abdullayeva

Using various nucleophil sulphur-containing reagents with 1,2-epitio-3-chlorpan, we obtained functionally-substituted tiirans which have been analyzed as additives to transmission oils with a view of improving their quality. It has been established that synthesized S-substituted derivatives of tiirans appreciably improve EP and wear-preventive properties of transmission…

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SYNTHESIS AND STUDY OF COMPLEX COMPOUNDS BASED ON FERRİC CHLORİDE (FeCI₃) REACTIONS WITH AMINO ACIDS

S.B. Zeynalov, S.K. Sharifova, E.R. Huseynov, F.A. Abdullayeva, M.G. Abbasov, A.K. Sharifova

Complex compounds of iron (III) chloride with representatives of aliphatic, aromatic and heterocyclic amino acids were synthesized. Structures of the obtained compounds were presented on the basis of IR-, UV-spectroscopy and by chemical analysis method. The Fe+3 complex with glycine was tested as a catalyst…

DOI: 10.32737/2221-8688-2020-2-229-236

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SYNTHESIS OF AMINOMETHYL DERIVATIVES OF 3-MERCAPTO-2-HYDROXYPROPYL-1-ISOBUTYL ETHER AND THEIR STUDY AS PROTECTIVE ADDITIVES TO LUBRICANT OILS

V.M. Farzaliyev, Sh.R. Aliyev, R.M. Babai, R.F. Mammadova, G.M. Guliyeva, A.M. Mammadov, G.Sh. Eivazova

The electrochemical corrosion prevention of engines and mechanisms is a task of great national, economic and defense importance. Lubricating oils commonly used in engineering do not have sufficient protective properties and are unable to effectively protect it from corrosion, both during operation and during short-term…

DOI: 10.32737/2221-8688-2023-1-48-56

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IR SPECTRA OF DIMOLYBDENUM TETRA-μ₂-PHENYLACETATE COMPLEX AND ITS DERIVATIVES

E.L. Akhmedov, S.Sh. Akberova, K.F. Huseynguliyeva, Sh.Y. Ismayilova

The study describes the synthesis, thermal and spectral characteristics of tetra-μ2-phenylacetate complex of dimolybdenum – Мо2(O2CCH2C6H5)4 and its derivatives in the type [Мо2(O2CCH2C6H5)4]L2' [where L' = α-, β-picoline (α-, β-Pic), 4-vinylpyridine (4-VinPy), quinoline (Q). The comparison of IR spectra of the synthesized [Мо2(O2CCH2C6H5)4]L2' complexes with…

DOI: 10.32737/2221-8688-2024-1-45-51

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SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF [1,2,4]TRIAZOLO[4,3-B][1,2,4,5]TETRAZINE DERIVATIVES

Bassam A. Hassan, Athraa H. Mekky

A series of fused heterocyclic compound triazolotetrazine were prepared from the reaction of equimolar amount of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol via cyclization addition reaction with different aromatic aldehydes in presence of piperidine as catalyst to produce the target [1,2,4]triazolo[4,3- b][1,2,4,5] tetrazine derivatives. The synthesized compounds were characterized by…

DOI: 10.32737/2221-8688-2025-1-78-94

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SYNTHESIS, CHARACTERIZATION OF A NEW COMPOUND 22-(3,5-BIS(3,5,5,6TETRAMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2-THIAZIN-2-YL)PHENYL)-3,5,5,6TETRAMETHYL-5,6-DIHYDRO-2H-1,2-THIAZINE 1,1-DIOXIDE, AND STUDY OF ITS BACTERIAL AND FUNGAL ACTIVITY AND MOLECULAR DOCKING

Marwan M. Farhan

Abstract: A synthesis of a new compound (II) with three groups of 1,2-thiazine 1,1-dioxide, called (2-(3,5-bis(3,5,5,6-tetramethyl-1,1-dioxido-5,6-dihydro-2H-1,2-thiazin-2-yl)phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-2H-1,2-thiazine 1,1-dioxide ), was synthesized by reacting moles (1:3) of each of benzene-1,3,5-triamine with 3,4,4,6-tetramethyl-3,4-dihydro-1,2-oxathiine 2,2-dioxide (I), respectively. The last compound (I) was prepared by equal moles of each of…

Keywords: Synthesis, new compound, -1,2-thiazine 1,1-dioxide, Dugong, fungi, bacteria

DOI: 10.65382/2221-8688-2026-1-31-41

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SYNTHESIS, CHARACTERIZATION, ENZYMATIC ACTIVITY OF SOME PYRAZOLINE DERIVATIVES, AZO DYES, AND CHALCONES DERIVED FROM ETHYL 4-(TRIFLUOROMETHYL)BENZOATE

Sh.H. Abdullah¹, A.B. Saber¹, K.A. Al-Badrany¹, J.N. Saleh², M.J. Saleh²

Abstract: This study reports the use of 4-(trifluoromethyl)benzoate as a key synthone for preparing a series of heterocyclic derivatives. Reaction completion was verified by thin-layer chromatography (TLC), and the products were characterized by physical properties (color, yield, and melting point), Fourier-transform infrared spectroscopy (FT-IR), and…

Keywords: chalcone, azo dyes, pyrazine, acid hydrazide, enzymatic activity

DOI: 10.65382/2221-8688-2026-3-346-361

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