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PREPARATION AND CHARACTERIZATION OF INDOLE-3-CARBALDEHYDE-DERIVED PYRAZOLINE DERIVATIVES AND EVALUATION OF BIOLOGICAL EFFICACY

J.H. Saleh, M.G. Abdulkarim

Abstract: The research involved the preparation of a series of chalcones [I1-I5] by the reaction of indole-3-carbaldehyde with acetophenone substituents in a basic medium. The prepared chalcones were then reacted with aqueous hydrazine in the presence of glacial acetic acid as a catalyst to form…

Keywords: heterocyclic; chalcones; pyrazoline; biological activity

DOI: 10.65382/2221-8688-2026-4-599-569

SYNTHESIS, CHARACTERIZATION, ENZYMATIC ACTIVITY OF SOME PYRAZOLINE DERIVATIVES, AZO DYES, AND CHALCONES DERIVED FROM ETHYL 4-(TRIFLUOROMETHYL)BENZOATE

Sh.H. Abdullah¹, A.B. Saber¹, K.A. Al-Badrany¹, J.N. Saleh², M.J. Saleh²

Abstract: This study reports the use of 4-(trifluoromethyl)benzoate as a key synthone for preparing a series of heterocyclic derivatives. Reaction completion was verified by thin-layer chromatography (TLC), and the products were characterized by physical properties (color, yield, and melting point), Fourier-transform infrared spectroscopy (FT-IR), and…

Keywords: chalcone, azo dyes, pyrazine, acid hydrazide, enzymatic activity

DOI: 10.65382/2221-8688-2026-3-346-361

BENZAMINE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY

Zahraa S. Qasim, Kareem S. Abbas

Our study is included the synthesis of a number of benzamide drivatives through two chemical processes. The first is the benzoylation of some aromatic amines containing a pyrimidine or a pyrazoline ring in their structures (A-G) using benzoyl chloride or p-chloronbenzoyl chloride in the presence…

DOI: 10.32737/2221-8688-2024-4-411-435