Chemical Problems; 2026; V. 24(4); p. 525-539
SYNTHESIS, CHARACTERIZATION AND STUDY OF THE ANTIBACTERIAL ANDANTIOXIDANT ACTIVITY OF Cu(II) and Cd(II) COMPLEXES USING MANNICH BASES AND PHOSPHINATES (dppe, dppp) AS LIGANDS
College of Education for Pure Science, Department of Chemistry, Tikrit University, Tikrit, Iraq
E-mail:
AH230028pep@st.tu.edu.iq
Received Date: 2025-07-09
Accepted Date: 2025-09-18
Keywords:
Complex, Mannich bases antioxidant, Biological activity, Cu(II), Cd(II).
Notes:
Abstract: Drug-resistant bacteria, especially multidrug-resistant strains, chronic infections, and emerging pathogens, continue to evolve and spread widely. This development places a significant burden on the global healthcare system, and there is an urgent need to develop new and highly effective antibacterial drugs. In this study, several Mannich bases derived from 2-aminothiazole and diphenylbenzene with benzaldehyde substitutes were prepared. The prepared Mannich bases were used as ligands to prepare copper and cadmium complexes. Finally, the prepared complexes were reacted with phosphines (dppe, dppp) to prepare various complexes in an attempt to synthesize more potent compounds. Physical characteristics such as melting point and color were used to validate the structures of the free compounds. The compounds were also characterized spectroscopically using infrared spectroscopy, proton and phosphorus nuclear magnetic resonance (NMR), quantitative elemental analysis (C.H.N.), and magnetic susceptibility studies of the formed complexes. Some compounds showed good activity against Gram-negative and Gram-positive bacteria, with compound (A34) having the largest share, as it showed excellent activity, reaching an inhibition rate of (34 mm) against Staphylococcus aureus and an inhibition rate of (24 mm) against Escherichia coli. In an additional study, the antioxidant activity of the compounds prepared outside the body was studied, where the compound (A34) showed excellent activity, reaching (58.75%) and this is a good indicator of the effectiveness of the compounds as antioxidants.