Abstract
Our study is included the synthesis of a number of benzamide drivatives through two chemical processes. The first is the benzoylation of some aromatic amines containing a pyrimidine or a pyrazoline ring in their structures (A-G) using benzoyl chloride or p-chloronbenzoyl chloride in the presence of 1,4- dioxan as solvent productive (N1-N6, N13-N16) derivatives. The second is the tosylation of (N2-N6, N15) by p-toluene sulfonyl chloride in the presence of pyridine as catalyst and base at room temperature to produce (B1-B6 ) derivatives . The products have been characterized by IR, 1H-NMR ,13 C-NMR and mass spectroscpies and the physical properties of the products are recorded . The spectral data confirmed the validity of the benzamide derivatives. Also the work is included the study of antimicrobial activity of the synthesized compounds represented by determining the inhibition diameter zone (IZ), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) given by these compounds against the test organisms Staphylococcus aureas (Gr+positive) and Escherichia coli (Gr- negative). Furthermore, the results of MIC and MBC were compared with those of some common antibiotics such as tetracycline, ampicillin and streptomycin. This comparison showed that it is possible to use the synthesized derivatives as antimicrobials.