Abstract
New complex compounds of palladium (II) with the biologically active ligand 2-ethyl-6 methyl-3- hydroxypyridine – mexidol were synthesized in acidic (pH=5.3) and slightly alkaline (pH=7.5) media, respectively, of the following composition: (C8H12ON+)2[PdCl4] – (HL)2[PdCl4] (I) and [Pd(C8H11NO)2Cl2] – [PdL2Cl2] (II). In complex I, two ligand molecules are protonated and occupy the outer coordination sphere as singly charged cations. In complex II, the ligands are coordinated monodentately via the nitrogen atom in the trans-position to each other. Complexes I and II were tested for radioprotective properties. The toxicity of complexes I and II is LD50 – 240 mg/kg and 256 mg/kg of animal weight, respectively. The biological test showed that complexes I and II, along with radioprotective properties, also have some antitumor activity.