Abstract
Conditions for alkoxymethylation of 2-aminothiazole with semiformals obtained by the interaction of aliphatic alcohols with formaldehyde were worked out. Alkoxymethylation was performed by means of preliminary preparation of the semiformal of appropriate hydroxyl- containing compounds followed by interaction of semiformal with equimolar amount of 2- aminothiazole. The structure of the obtained compounds was acknowledged by means of IR and NMR 1 H spectroscopy. It was established that the reaction of the alkoxymethylation proceeds in the amino form of the starting 2-aminothiazole to form an appropriate monosubstituted N- alkoxymethyl derivative. As a result of microbiological tests, it was established that these compounds have high bactericidal properties against microorganisms which affect petroleum products and, at a concentration of 0.5%, completely protect both M-8 lubricating oil and diesel fuel from damage by bacteria even in terms of their forced infection. It found that at a concentration of 100 mg/l the obtained compounds protect the CT-3 steel from acid corrosion, moreover N-(isopropoxymethyl)thiazol-2-amine has the greatest protection effect.