Abstract
Pharmaceutical polymers based on glycogen as prodrugs were synthesized to enhance the physical and chemical properties, thereby increasing the solubility of the drugs compared to the original drugs. This improvement leads to better efficacy and bioavailability, enhancing their absorption and distribution within the body. The drug release process in prodrugs contributes to sustained pharmacological effects, extending the duration of therapeutic effects compared to immediate-release formulations. This research involves the preparation of pharmaceutical polymers [FA6-FA10] based on glycogen through the reaction of glycogen with maleic anhydride, followed by the addition of thionyl chloride and amino drugs to obtain new pharmaceutical polymers. These polymers were characterized spectrally using Fourier-transform infrared (FTIR) spectroscopy and proton nuclear magnetic resonance (1H NMR) spectroscopy. The physical properties of the polymers, such as swelling, viscosity, and controlled drug release in acidic, basic, and neutral media, were studied. The antibacterial properties were also investigated against two types of bacteria, namely Gram-positive and Gram-negative bacteria, using the disk diffusion technique. The results were compared with corresponding antibacterial drugs, indicating an increase in the antibacterial activity of the pharmaceutical polymers.