Abstract
This work describes the preparation and spectroscopic investigation of new heterocyclic compounds derived from the 4-aminoantipyrene moiety. The compound (R1)3-((1,5-dimethyl-3-oxo-2- phenyl-2,3-dihydro-1H-pyrazol-4-yl)diaz-enyl)-4-hydroxybenzaldehyde was prepared by reacting 4- aminoantipyrene with 4-Hydroxybenzaldehyde according to the cold condition at (0-5) Celsius. This represents the starting point to create novel azo-chalcone compounds with a new nucleus as the alpha-beta unsaturated group, and the formation of compound (R2-6) via acetophenone derivatives using ethanol as a solvent under a basic medium, and for synthesis of various compounds of 4-((5-((Z)-3-argio-3-oxoprop-1-en- 1-yl)-2-hydroxyphenyl)diazenyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one, using the cyclization of these compounds via (urea and hydrazine hydrate) to forming five and six novel heterocyclic rings of 4- ((5-(2-amino)-4-Argyo-6H-1,3-oxazine-6-yl)-2-hydroxyphenyl(diazenyl)-1,5-dimethyl-2-phenyl-1,2-dihydro- 3H-pyrazole-3-one [R7, 11], and 4-((5-(5-(4-argiophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-2- hydroxyphenyl)diazenyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazole-3-one [R12,16], respectively. Some diagnostic measurements have been used to characterize these molecules, such as melting point, thin-layer chromatography, measuring Nuclear Magnetic Resonance, Spectroscopy in the Infrared, and Mass Spectrometry, and determining the effectiveness of some of these compounds by diagnosing their effectiveness against types of pathogenic bacteria.