PREPARATION OF OXAZEPINE DERIVATIVES BY FUSION METHOD AND EVALUATION OF BIOLOGICAL AND LASER ACTIVITY

Abstract: In this study, some oxazepine-4,7-dione derivatives (SH8-SH13) were prepared from Schiff bases by reacting them with maleic anhydride without using solvents, using the fusion method, which is considered a safe, environmentally friendly, cost-effective, and time-saving method. The compounds were characterized using several spectroscopic techniques, such as FT-IR, UV-Vis, NMR, and GC-Mass. The structural results confirmed the successful synthesis process and the formation of the distinctive seven-membered ring of oxazepine compounds. The biological study showed that the prepared compounds possessed moderate to good activity against the two types of bacteria studied, Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Some compounds, such as SH10 and SH12, outperformed the others in terms of the diameter of the inhibition zone. It is worth noting that their activity against negative bacteria was higher than their activity against positive bacteria, likely due to the difference in cell wall composition. The compounds were irradiated with a helium-neon laser for four time periods (15, 30, 45, and 60 seconds), and then their physical properties were studied again. The compounds showed stability in the direction of the periods from 15 to 45 seconds, but at 60 seconds, a difference was found in the color, melting point, and RF.