Abstract: This paper investigates alternative conditions for synthesizing salts and toluidides of toluidine isomers with oxalic acid, malonic, and succinic acids. In these syntheses, the salt formation reactions of toluidines with oxalic acid in a 2:1 molar ratio and with malonic and succinic acids in a 1:1 molar ratio at room temperature in ethanol for 30 minutes to 7 days, and for the synthesis of amide-linked compounds, heating in toluene for 3 hours, were shown as alternative conditions. The structure of the obtained compounds was studied using modern physicochemical research methods such as IR spectrum, PMR analysis, and X-ray analysis.
Chemical Problems; 2026; V.24(1); p. 62-71
REACTIONS OF TOLUIDINE ISOMERS WITH OXALIC, MALONIC, AND SUCCINIC ACIDS
U.Ch. Akhmedov1* 
0009-0000-0501-3212, , ,
0009-0000-0501-3212, , , 1 Termez State University of Engineering and Agrotechnologies. Termez, 190100, Uzbekistan
2 Faculty of Chemistry, National University of Uzbekistan, Tashkent, 100034, Uzbekistan
3 Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Tashkent 100125, Uzbekistan
Email:
akhmedov@tdmau.uz
ORCID:
0009-0000-0501-3212
Received: 2025-01-28
Accepted: 2025-03-03
Keywords:
toluidine isomers, oxalic acid, malonic acid, succinic acid, quaternary salt and toluidine, IR-spectrum, 1H NMR and X-ray analysis.
https://doi.org/10.65382/2221-8688-2026-1-62-71
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