SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION FOR ESTER DERIVATIVES FROM SOME NSAIDS DRUGS

Abstract: The current research involves the synthesis of some NSAID derivatives and evaluating their antimicrobial and antioxidant activity. Briefly, some NSAID compounds were converted into ester derivatives using the Fischer esterification method. The synthesized compounds were spectrometrically characterized via modern methods FT-IR, ¹H-NMR, and ¹³C-NMR spectra. Antibacterial results showed good activity for Z1, Z2, and Z5 derivatives toward Escherichia coli compared to Ciprofloxacin. Also, compounds Z2 and Z4 exhibited good inhibition of Candida albicans compared to Fluconazole. In addition, the results of the DPPH investigation revealed good antioxidant activity for derivatives Z1 and Z5, with inhibition percentages of 91.22 and 86.51%, respectively, compared to ascorbic acid. Certainly, the results obtained have reinforced the importance of the synthesized compounds.