Abstract
Nowadays there are various antifungal agents. These included many substances, including derivatives of dithiocarbamates. The article aims to synthesize new derivatives of dithiocarbamate and study their antifungal activity. To analyze and identify synthesized substances and determine their structural formulas, the following spectral methods were used: IR (Shimadzu 8400 FTİR), 1H NMR (Bruker 500 MHz UltraShield) in DMSO-d6 (internal standard – tetramethylsilane), Mass spectroscopy (Agilent 1100 Series LC / MSD Trap VL & SL). Elemental analysis (C, H və N) was performed using a Perkin Elmer analyzer. The biological activity of synthesized derivatives of dithiocarbamates was explored and 100µg/ml dilution of compound J2 (2-((4- morpholinophenyl)amino)-2-oxoethyl 4-benzylpiperazine-1-carbodithioate) showed identical effect against Candida albicans, Candida crusei, Candida parapsilosis as fluconazole. Compound A4 (2-((4-(4- methylpiperazin-1-yl)phenyl)amino)-2-oxoethyl-4-methylpiperazine-1-carbodithioate) showed the same activity against Candida parapsilosis and Candida glabrata as a standard drug.