Chemical Problems; 2026; V. 24(4); p. 645-650
SYNTHESIS AND CHARACTERIZATION OF POLYPYRROLE FOR BIODETECTION
Chemistry department, College of science, Al anbar university, Iraq- Ramadi
E-mail:
ammar.moh@uoanbar.edu.iq
Received Date: 2025-06-10
Accepted Date: 2025-08-22
Keywords:
polypyrrole, creatinine, urea, glucose and uric acid
Notes:
Abstract: This work involves the synthesis of polypyrrole (PPy) and its application as a non-enzymatic electrochemical sensor for biologically relevant analytes such as creatinine, urea, glucose, and uric acid. A low-cost and readily available material was used to prepare a conductive polymer (polypyrrole) that was used in biodetection using a non-enzymatic method. This is a novel approach that gave positive results compared to other studies conducted using an enzymatic method or the presence of nanomaterials. PPy was prepared using the chemical oxidative polymerization of pyrrole. Ammonium peroxodisulphate and hydrochloric acid were used as an oxidizing and doping agent, respectively. The resulting PPy was deposited onto ITO glass substrates to fabricate modified electrodes. The structural, morphological, and chemical properties of PPy were characterized using FTIR spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). Electrochemical characterization and analytical performance evaluation were carried out using cyclic voltammetry. The PPy-based electrodes exhibited a strong and distinct electrochemical response toward creatinine and urea, demonstrating their promising sensing capability. In contrast, no significant voltammetric response was observed for uric acid and glucose under the same conditions, indicating selective sensitivity. This novel, enzyme-free sensing approach demonstrates advantages over conventional enzymatic and nanomaterial-based methods, presenting an efficient and cost-effective route for biomolecular detection.