SYNTHESIS AND CHARACTERIZATION OF SOME HYDRAZONE AND THIAZOLIDINE DERIVATIVES AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY

Abstract: In this study, hydrazone and thiazolidine derivatives were synthesized. The hydrazone derivatives (F2–F6) were prepared from 3-bromomethylbenzohydrazide, followed by their reaction with thioglycolic acid to form thiazolidine derivatives (F7–F11). The structures of the synthesized compounds were confirmed through physical changes, such as variations in melting point and color, in addition to spectroscopic analyses, including FT-IR, ¹H-NMR, and ¹³C-NMR. The antibacterial activity of the synthesized compounds was evaluated against two types of bacteria: Escherichia coli and Staphylococcus aureus. The compounds showed varying activity levels ranging from good to excellent.