Abstract
The new representatives of functionally substituted pyrazoles were synthesized and their interactions with secondary amines studied. It found that the interaction of 3,4-bis(diethylamino)but-2- en-1-ones with hydrazine hydrate gave rise to 3-alkyl-5-(diethylaminomethyl)pyrazoles. Appropriate 1- acetyl and 1-(2-chloromethyl carbonyl)pyrazoles were synthesized through the acylation of the last products with acetyl- and monochloroacetyl chloride in the presence of triethylamine. It revealed that 1- (2-chloromethyl carbonyl)pyrazoles react with twofold quantity of diethylamine and morpholine under mild reaction conditions to form new polyfunctional pyrazole derivatives. The composition and structure of the synthesized compounds were confirmed by IR- and NMR 1Н-spectroscopy. It established that 3-methyl- and 3-ethyl-5-(diethylaminomethyl) pyrazoles were biologically active substances out of synthesized functionally pyrazole derivatives.