SYNTHESIS, CHARACTERIZATION, AND EVALUATION OF BIOLOGICAL AND LASER ACTIVITIES OF SOME NOVEL AZETIDINONE DERIVATIVES

Abstract: Azetidinone rings [M11-M15] were produced as part of this research by reacting pre-synthesized Schiff bases with chloroacetyl chloride in the presence of dioxane as a solvent using conventional methods and sublimation for 9-10 hours. Using spectroscopic techniques, including infrared spectroscopy and proton nuclear magnetic resonance spectroscopy, the structures of the resulting compounds were verified. Physical properties such as color, melting point, and product yield were evaluated using two bacterial isolates known to be resistant to antibiotics (Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus), with amoxicillin as the control antibiotic. Comparison with the results of the control antibiotics showed that they were effective. They had good inhibitory activity against both bacteria and were highly potent and selective. A helium-neon laser (visible laser) was used to test the laser activity of the produced compounds. Each compound was irradiated for four different time periods (15, 30, 45, and 60 seconds), after which its physical properties were evaluated. The preparation was examined again, and the changes in the compounds were recorded.