Abstract
By the region-selective, a click one-pot reaction a series of new 1,2,3-triazole derivatives were successfully synthesized and evaluated in vitro as antioxidant agents. The molecular structures of synthesized derivatives were characterized using spectral analysis (IR, 1H NMR, and 13C NMR) in addition to elements analysis (C.H.N). The products obtained were investigated in vitro for their antioxidant activity. The results of the DPPH test revealed that 1,2,3-triazole derivatives possess a good selectivity index to capture free radicals. It was found among these compounds that the 5a, 5c and 5d exhibited potent levels of activity with inhibition percentages of 82.25, 80.42, and 75.36%, respectively compared to that of standard ascorbic acid. In addition, the molecular docking study confirmed the biological activity results of the tested compounds and determined their interactions nature with the active site of the protein.