SYNTHESIS, CHARACTERIZATION OF A NEW COMPOUND 22-(3,5-BIS(3,5,5,6TETRAMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2-THIAZIN-2-YL)PHENYL)-3,5,5,6TETRAMETHYL-5,6-DIHYDRO-2H-1,2-THIAZINE 1,1-DIOXIDE, AND STUDY OF ITS BACTERIAL AND FUNGAL ACTIVITY AND MOLECULAR DOCKING

Abstract: A synthesis of a new compound (II) with three groups of 1,2-thiazine 1,1-dioxide, called (2-(3,5-bis(3,5,5,6-tetramethyl-1,1-dioxido-5,6-dihydro-2H-1,2-thiazin-2-yl)phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-2H-1,2-thiazine 1,1-dioxide ), was synthesized by reacting moles (1:3) of each of benzene-1,3,5-triamine with 3,4,4,6-tetramethyl-3,4-dihydro-1,2-oxathiine 2,2-dioxide (I), respectively. The last compound (I) was prepared by equal moles of each of (4-methylpent-3-en-2-one) with (sulfonylethane). The structural formula of the resulting compounds was confirmed by their spectroscopic identification (FT-IR, ¹H-NMR, ¹³C-NMR). The effect of these two compounds at different concentrations (0.01, 0.1, 1.0, and 10 mg/ml) on the growth of six types of Gram-negative and positive bacteria (Protans vulgarisginosa, Staphylococcus aureus, Pseudonas aeruginosa, Bacillus subtillus, and Enterbacter sp.) was studied. Compared with the pharmaceutical compound Chloramphenicol, it shows high inhibition values at concentrations (1.0 and 10 mg/ml) and exceeds the reference’s inhibition limit. It is also noted that the concentrations of the acid compound (0.01 and 0.1 mg/ml) are acceptable. The effect of these two compounds was also measured using concentrations (10, 25, and 30 mg/ml) on the growth of fungi A. fumigates, T.mentagrophytes, C.albicans and M. canis zone (killing). For the concentrations of the prepared compounds, the killing range of compound (II) is much higher compared to compound (I). Furthermore, molecular docking studies have revealed many correlations with amino acid residues in active sites, so these results have the potential to stimulate further research on heterocyclic compounds.