SYNTHESIS OF AROMATIC-HETEROCYCLIC AMINO ALCOHOLS AND INVESTIGATION OF THEIR ANTIBACTERIAL AND PHYSIOLOGICAL PROPERTIES

Amino alcohols are important compound in point of physiological activity. A number of aromatic and heterocyclic amino alcohols were efficiently prepared and characterized by using spectroscopic data. They were also evaluated for antibacterial activity against both Gram-positive and Gram-negative bacteria in vitro comparable to cefalexin. The compound 10 showed excellent activity against Bacilus cereus (ATCC, 11778), Sarcina lutea (ATCC, 9341), Salmonella typhimurium (1,4,5,12:;::1,2) and Escherichia coli (ATCC, 29998) compared to Cefalexin.