Abstract
In this study, the authors chemically synthesized new theophylline derivatives and then evaluated them in vitro as antimicrobial agents. The target derivatives, theophylline derivatives conjugated with 1,2,3- triazole and piperazine moieties, were synthesized via sequential various reactions. Spectroscopically, the researchers employed FT-IR, 1H NMR, and 13C NMR techniques to get further insights into these derivatives; they also used the CHN technique to facilitate their structure identification. In addition, the authors conducted tests in vitro to evaluate the antibacterial activity of all the synthesized derivatives against E. coli and S. aureus. The study results obtained showed encouraging antibacterial efficacy.