CHEMICAL PROBLEMS

Abstract: This study included the preparation of several hexagonal rings derived from pyrimidines. Alpha-beta-unsaturated compounds were prepared by reacting 4-methyl thiazole-5-carbaldehyde with acetophenone substitutes. This step was considered the nucleus for the preparation of hexagonal rings. Then, the alpha-beta-unsaturated compounds were treated with several reagents to obtain pyrimidine derivatives in equal molar ratios. They reacted […]

Abstract: A rapid and sensitive spectroscopic method was developed for the determination of thymol in its pure form and in its pharmaceutical preparations. The method relied on oxidative coupling reactions. With the oxidizing agent N-chlorosuccinimide and the p-anisidine reagent in a basic sodium hydroxide medium to form a stable, blue-colored product that gives maximum absorption […]

Abstact: A sensitive, rapid, and accurate spectrophotometric method was proposed for the determination of rosuvastatin calcium (ROS-Ca) using nucleophilic addition reactions. The acetylation reaction is an important reaction resulting from the reaction of alcohol groups with aldehydes or ketones, which gives products with distinctive colors. This method is based on the acetylation formation from the […]

Abstract: A novel macrocyclic ligand, 2,5,7,10-tetraaza-1,6(1,3)-dibenzenacyclodecaphane-3,4,8,9-tetraone (TF), was synthesized via solid-state microwave-assisted condensation of oxalic acid with m-phenylenediamine. Upon reaction with selected divalent transition metal ions, the ligand formed stable coordination complexes of the general formula [M(TF)₂Cl₂], where M = Cu, Co, or Zn. The structures of the ligand and its complexes were comprehensively characterized […]

Abstract: Breast cancer is considered one of the increasingly serious problems affecting women recently, so many parties are seeking to find effective solutions that reduce its risks. Therefore, the research paper aimed to synthesize hydrazide–hydrazones of isoniazid (T1–T5), which underwent reaction with trichloroacetic acid (TCA), resulting in the synthesis of a series of 4,4-dichloro-1,3-oxazolidine-5-one derivatives […]

Abstract: Azetidinone rings [M11-M15] were produced as part of this research by reacting pre-synthesized Schiff bases with chloroacetyl chloride in the presence of dioxane as a solvent using conventional methods and sublimation for 9-10 hours. Using spectroscopic techniques, including infrared spectroscopy and proton nuclear magnetic resonance spectroscopy, the structures of the resulting compounds were verified. […]

Abstract: This research examines the effect of annealing temperature on the phase, optical, and structural characteristics of ZnO nanopowder. Characterization of samples was carried out using a combination of Raman spectroscopy, scanning electron microscopy (SEM), UV-visible spectroscopy, and X-ray diffraction (XRD) methods. The degrees of amorphousness and crystallinity were determined using the Search Match 3 […]

Abstract: A simple, cost-effective, and highly sensitive spectrophotometric method was developed for the determination of folic acid (vitamin B9). The method is based on an oxidative coupling reaction with a synthetic reagent, (E)-N’-(1-(2-nitrophenyl)ethylidene)quinoline-6-carbohydrazide (M4), in the presence of potassium dichromate as the oxidizing agent and sodium hydroxide in a basic medium. This reaction produces a […]

Abstract: This research combines the synthesis of several hexagonal and heptacyclic compounds derived from Schiff bases. The Schiff bases were prepared by incorporating [d][1,3]dioxol-5-carbaldehyde with aniline substituents used as nucleophiles. Several heptacyclic oxazapanes were prepared by incorporating Schiff bases with succinic anhydride, and several hexagonal thiazenanes were prepared by incorporating Schiff bases with 2-mercaptopropanoic acid. […]

Abstract: Some problems of ligand substitution reactions in non-regular condensed systems are considered in this work. One of the aspects of theoretical research is the study of the properties of individual particles, taking into account the nano-dimension of the molecules of the condensed system surrounding the particle. Two main mechanisms of influence on ligand particles […]