CHEMICAL PROBLEMS

Abstract: In this study, the sublimation technique was employed to react equimolar amounts of Schiff base derivatives with sodium azide in the presence of DMSO as a solvent for 21 –22 hours. The result is a synthesis of five-membered tetrazole derivatives. Physical and spectroscopic techniques, including infrared, proton and carbon nuclear magnetic resonance, validated the […]

Abstract: A sequence of 6-(6-(methylthio)-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole [5a], 6-(6-(ethylthio)-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole [5b], 3-phenyl-6-(propylthio)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole [5c] has been designed. The spectral analyses validated the synthesis of novel 6-(Alkylthio)-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole, which was examined using FT-IR, 1H-NMR, 13C-NMR, and mass spectrometry. The ADME profiles demonstrated favorable oral bioavailability and pharmacokinetic characteristics. These parameters were investigated because many synthesized compounds often fail at later stages […]

Abstract: A simple and accurate spectrophotometric method was developed for the determination of dopamine hydrochloride and methyldopa. This method depends on the oxidative coupling reaction of these compounds for paracetamol hydrolysis. It utilizes a potassium bromide-bromate mixture as an oxidative agent in a basic solution and CPC as a surfactant. A violet and blue color […]

Abstract: In this study, hydrazone and thiazolidine derivatives were synthesized. The hydrazone derivatives (F2–F6) were prepared from 3-bromomethylbenzohydrazide, followed by their reaction with thioglycolic acid to form thiazolidine derivatives (F7–F11). The structures of the synthesized compounds were confirmed through physical changes, such as variations in melting point and color, in addition to spectroscopic analyses, including […]

Abstract: Oncology extensively uses nanographene, an inorganic nanocomposite material, because of its ability to deliver drugs, its adaptability, and its photothermal and photodynamic effects. However, the restricted use of the abovementioned features limits its current use. This is mainly because graphene oxide nanoparticles’ physical and chemical characteristics are poorly understood. Two nanocomposites, R1, were formed […]

Abstract: This study reports the use of 4-(trifluoromethyl)benzoate as a key synthone for preparing a series of heterocyclic derivatives. Reaction completion was verified by thin-layer chromatography (TLC), and the products were characterized by physical properties (color, yield, and melting point), Fourier-transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (¹H- and ¹³C-NMR). The corresponding hydrazide […]

Abstract: A spectroscopic method has been developed to determine the mesalazine in both its pure form and pharmaceutical preparations. The procedure is characterized by its simplicity, rapidity, and high sensitivity. It relies on the oxidative coupling reaction between mesalazine and benzidine in the presence of ferric chloride as an oxidizing agent within a hydrochloric acid […]

Abstract: The aim of this method is to develop a simple, accurate, sensitive, inexpensive, indirect spectrophotometric assay of mebendazole in pharmaceutical formulation (tablets) and pure form. The suggested technique relies on the oxidation of mebendazole by the addition of a known excess amount of calcium hypochlorite in an acidic medium at room temperature. Then unreacted […]

Abstract: Drug-resistant bacteria—including multidrug-resistant strains, persistent infections, and emerging pathogens—continue to spread rapidly, posing a serious threat to global public health. This situation highlights the urgent need to develop new, highly effective antimicrobial agents. In this study, a series of tetrazole derivatives were synthesized as potential antibiotic candidates. The compounds were prepared via the conventional […]

Abstract: Currently, surface-active agents (surfactants) have found widespread application in various industries, including detergents, foaming agents, emulsion stabilizers, fluorogens, hydrophobizers, and corrosion inhibitors. As a result, the synthesis of surfactants has become a critical area of study. This paper presents the results of an investigation into the oil-repelling and oil-dispersing properties of complex salts formed […]